
Tsung-Shing Wang Lab
Organic Chemistry & Chemical Biology
台灣大學化學系王 宗興實驗室
PUBLICATIONS
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Pal, Arnab; Suresh, Sreerag; Khan, Arshad; Kuo, Li Huai; Chi, Li Tang; Ganguly, Anindita; Kao, Chih-Yao; Sharma, Manish Kumar; Wang, Tsung-Shing Andrew; Kang, Dun-Ye; Lin, Zong-Hong “Metal-organic frameworks as thermocatalysts for hydrogen peroxide generation and environmental antibacterial applications” Sci. Adv. 2025, 11(2), eads4711 DOI: 10.1126/sciadv.ads4711

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Kao, Chih-Yao; Chen, Ying-Wei; Liu, Yu-Cheng; Wei, Jen-Hsuan; Wang, Tsung-Shing Andrew* “Versatile Stimuli-Responsive Controlled Release of Pinanediol-Caged Boronic Esters for Spatiotemporal and Hypoxia-Selective Glucose Bio-imaging” ACS Sens. 2024, ASAP DOI: 10.1021/10.1021/acssensors.4c02811

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Ai-Lin Chen; Zih-Jheng Lin; Hsiao-Yu Chang; Tsung-Shing Andrew Wang* “Chemoselective Stabilized Triphenylphosphonium Probes for Capturing Reactive Carbonyl Species and Regenerating Covalent Inhibitors with Acrylamide Warheads in Cellulo” J. Am. Chem. Soc. 2024, ASAP DOI: 10.1021/jacs.4c09727

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Lin, S.-T.; Wang, C.-H.; Chen, A.-L.; Wang, T.-S. A.* “Utilizing Alkyne-Nitrone Cycloaddition for the Convenient Multi-Component Assembly of Protein Degraders and Biological Probes” Chem. Eur. J. 2024, DOI: 10.1002/chem.202403184

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Wang, T.-S. A.*; Chen, P.-L.; Chen, Y.-C. S.; Chiu, Y.-W.; Lin, Z.-J.; Kao, C.-Y.; Hung, H.-M. “Evaluation of the Stereochemistry of Staphyloferrin A for Developing Staphylococcus-Specific Targeting Conjugates” ChemBioChem 2024, e202400480. DOI: 10.1002/cbic.202400480

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Tsai, C.-Y.; Chen, P.-H.; Chen, A.-L.; Wang, T.-S. A.* “Spatiotemporal Investigation of Intercellular Heterogeneity via Multiple Photocaged Probes” Chem. Eur. J. 2023, 29(52), e202301067. DOI: 10.1002/chem.202301067

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Wang, T.-S. A*.; Zhang, Y.-W.; Chen, H.-A.; Lin, S.-T.; Lee, H.-M. “Constructing pH-Responsive and Tunable Azo-Phenol-Based o-Nitrobenzyl Photocages” Chem. Eur. J. 2023, 29(40), e202300884. DOI: 10.1002/chem.202300884

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Io W.-S.; Wang, T.-S. A.* “A Versatile Strategy to Manipulate and Probe Native Carbonic Anhydrases In Cellulo Utilizing Two-Step Ligand-Directed Functionalization” ACS Chem. Biol. 2023, 18, 5, 1208–1217 DOI: 10.1021/acschembio.3c00102

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Hung, H.-M.; Wang, T.-S. A.* "A Double Photocage Strategy to Construct Light-Controllable and Spatiotemporally Trackable Cathepsin B Activity-Based Probes." ACS Chem. Biol. 2022, 17, 1, 11-16 DOI: 10.1021/acschembio.1c00705

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Wang, T.-S. A.*; Chen, P.-L.; Chen, Y.-C. S.; Hung, H.-M.; Huang, J.-Y. "Selectively Targeting and Differentiating Vancomycin-Resistant Staphylococcus aureus via Dual Synthetic Fluorescent Probes." ACS Infect. Dis. 2021, 7, 2584-2590. DOI: 10.1021/acsinfecdis.1c00235

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Fan, C.-H.; Wei, K.-C.; Chiu, N.-H.; Liao, E.-C.; Wang, H.-C.; Wu, R.-Y., Ho, Y.-J.; Chan, H.-L.; Wang, T.-S. A.; Huang, Y.-Z.; Hsieh, T.-H.; Lin, C.-H.; Lin, Y.-C.; Yeh, C.-K. "Sonogenetic-Based Neuromodulation for the Amelioration of Parkinson’s Disease." Nano Letters, 2021, 21, 5967-5976. DOI: 10.1021/acs.nanolett.1c00886

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Wang, T.-S. A.; Wu, R.-Y.; Hong, Y.; Wang, Z.-C.; Li, T.-L.; Shie, J.-J.; Hsu, C.-C. "Labeling and Characterization of Phenol‐Containing Glycopeptides Using Chemoselective Probes with Isotope Tags." ChemBioChem 2021, 22, 2415-2419. DOI: 10.1002/cbic.202100242
This work was highlighted as Cover Feature in the same issue
link: https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cbic.202100242

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Chung, H.-H.; Kao, C.-Y.; Wang, T.-S. A.; Chu, J.; Pei, J.; Hsu, C. C. "Reaction Tracking and High-Throughput Screening of Active Compounds in Combinatorial Chemistry by Tandem Mass Spectrometry Molecular Networking." Anal. Chem. 2021, 93, 2456-2463. DOI: 10.1021/acs.analchem.0c04481

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Chen, P.-C.; Ho, S.-Y.; Chen, P.-L.; Hung, T.-C.; Liang, A.-J.; Kuo, T.-F.; Huang H.-C,; Wang, T.-S. A.* “Selective Targeting of Vibrios by Fluorescent Siderophore-Based Probes” ACS Chem Biol. 2017 Oct 16. DOI: 10.1021/acschembio.7b00667.
Highlighted by Chem. Res. Toxicol., 2017, 30 (12), 2095–2096 DOI: 10.1021/acs.chemrestox.7b00316
link: http://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.7b00316

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Fan, C.-H.; Huang, Y.-S.; Huang, W.-E.; Lee, A. A.; Ho, S.-Y.; Kao, Y.-L.; Wang, C.-L.; Lian, YL.; Ueno T.; Wang, T.-S. A.; Yeh, C.-K.; Lin, Y.-C. “Manipulating Cellular Activities Using an Ultrasound-Chemical Hybrid Tool” ACS Synth Biol. 2017 Oct 12. DOI: 10.1021/acssynbio.7b00162.

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Ho, Y.-H.; Ho, S.-Y.; Hsu, C.-C.; Shie, J.-J.; Wang, T.-S. A.* “Utilizing an iron(III)-chelation masking strategy to prepare mono- and bis-functionalized aerobactin analogues for targeting pathogenic bacteria” Chem. Comm. 2017, 53, 9265-9268. DOI: 10.1039/C7CC05197B

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Luo, X.; Wang, T.S. (co-first author); Zhang, Y.; Wang, F.; Schultz, P. G. “Stabilizing Protein Motifs with a Genetically Encoded Metal-Ion Chelator” Cell Chem. Biol. 2016, 23, 1098-1102. DOI: 10.1016/j.chembiol.2016.08.007.

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Lee, A. A.; Chen, Y.-C.; Ekalestari, E.; Ho, S.-Y.; Hsu, N.-S.; Kuo, T.-F.; Wang, T.-S. “Facile and Versatile Chemoenzymatic Synthesis of Enterobactin Analogues and Applications in Bacterial Detection” Angew. Chem. Int. Ed. 2016, 55, 12338 –12342. DOI: 10.1002/anie.201603921.

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Tien, H.-W.;, Ou Y.-M.; Hsu R.-Y.; Wang T.-S.; Her G.-R. “Letter: The formation of a M + 2 Compound in the Analysis of a Trimethylsilyl Derivative of Monocarboxylic Acids by Gas Chromatography Electrospray Ionization Mass Spectrometry” Eur. J. Mass Spectrom. 2016, 22, 145-150. DOI: 10.1255/ejms.1418.
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Zhang, Y.; Goswami, D.; Wang, D.; Wang, T.-S.; Sen, S.; Magliery, T. J.; Griffin, P. R.; Wang, F.; Schultz, P. G. An antibody with a variable-region coiled-coil "knob" domain. Angew. Chem. Int. Ed. 2014, 53, 132-135. DOI: 10.1002/anie.201307939.

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Garg, N.; Oman T.J.; Wang, T.-S.; De Gonzalo CV.; Walker S.; van der Donk W.A. Mode of action and structure-activity relationship studies of geobacillin I. J Antibiot (Tokyo). 2014, 67, 133-136. DOI: 10.1038/ja.2013.112.
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Oman, T. J.; Lupoli, T. J.; Wang, T.-S.; Kahne, D.; Walker, S.; van der Donk, W. A. “Haloduracin α Binds the Peptidoglycan Precursor Lipid II with 2:1 Stoichiometry” J. Am. Chem. Soc. 2011, 133, 17544–17547.

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Lupoli, T. J.; Tsukamoto, H.; Doud, E.; Wang, T.-S.; Walker, S.; Kahne, D. “Transpeptidase- Mediated Incorporation of D-Amino Acids” J. Am. Chem. Soc. 2011, 133, 10748–10751.

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Wang, T.-S.; Lupoli, T. J.; Sumida, Y.; Tsukamoto, H.; Wu, Y.; Rebets, Y.; Kahne, D.; Walker, S. “Primer Preactiviation of Peptidoglycan Polymerases” J. Am. Chem. Soc. 2011, 133, 8528–8530

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Gampe, C. M.; Tsukamoto, H.; Wang, T.-S.; Walker, S.; Kahne, D. “Modular Synthesis of Diphospholipid Oligosaccharide Fragments of the Bacterial Cell Wall and Their Use to Study the Mechanism of Moenomycin and Other Antibiotics” Tetrahedron 2011, 67, 9771–9778.

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Fuse, S.; Tsukamoto, H.; Yuan, Y.; Wang T.-S.; Zhang, Y.; Bolla, M.; Walker, S.; Sliz, P.; Kahne, D. “Functional and Structural Analysis of a Key Region of the Cell Wall Inhibitor Moenomycin” ACS Chem. Biol. 2010, 5, 701–711.

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Perlstein, D. L.; Wang, T.-S.; Doud, E.; Kahne, D.; Walker, S. “The Role of the Substrate Lipid in Processive Glycan Polymerization by the Peptidoglycan Glycosyltransferases” J. Am. Chem. Soc. 2010, 132, 48–49.

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Lupoli, T. J.; Taniguchi, T.; Wang, T.-S.; Perlstein, D. L.; Walker, S.; Kahne, D. “Studying a Cell Division Amidase Using Defined Peptidoglycan Substrates” J. Am. Chem. Soc. 2009, 131, 18230–18231.

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Wang, T.-S.; Manning, S. A.; Walker, S.; Kahne, D. “Isolated Peptidoglycan Glycosyltransferases from Different Organisms Produce Different Glycan Chain Lengths” J. Am. Chem. Soc. 2008, 130, 14068–14069.
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This work was featured in NEWS OF THE WEEK, Chem. & Eng. News


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Barrett, D.; Wang, T.-S.; Yuan, Y.; Zhang, Y.; Kahne, D.; Walker, S. “Analysis of Glycan Polymers Produced by Peptidoglycan Glycosyltransferases” J. Biol. Chem. 2007, 282, 31964–31971.
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Perlstein, D. L.; Zhang, Y.; Wang, T.-S.; Kahne, D.; Walker, S. “The Direction of Glycan Chain Elongation by Peptidoglycan Glycosyltransferases” J. Am. Chem. Soc. 2007, 129, 12674–12675.

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Zhang, Y.; Fechter, E. J.; Wang, T.-S.; Barrett, D.; Walker, S.; Kahne, D. “Synthesis of Heptaprenyl-lipid IV to Analyze Peptidoglycan Glycosyltransferases” J. Am. Chem. Soc. 2007, 129, 3080–3081.

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Li, P.-C.; Wang, T.-S.; Lee, G.-H.; Liu, Y.-H.; Wang, Y.; Chen, C.-T.; Chao, I. “Theoretical Study and X-Ray Determination of Bianthrones: Long C-C Bond Length and Preferred Gauche Conformation” J. Org. Chem. 2002, 67, 8002–8009.
